From a Tezuka-centered perspective, the legacy of the Animerama films is difficult to assess. They were certainly pioneering, but the studio had to pay a heavy toll for that, and the mangaka grew increasingly estranged from his own staff. Things went slowly, but Tezuka gave up on Animerama after Cleopatra and, soon, on Mushi Production as a whole. Tezuka and his studio would go their separate ways: among the symbols of that split was the so-called third Animerama movie, Kanashimi no Belladonna.